The Krebs Institute is a multidisciplinary research centre with an overall theme of mechanistic biology. Mechanistic biology studies basic, life-governing, processes from the cellular to the atomic level. Such an approach requires a synergy of skills and expertise from across the scientific disciplines. At the heart of the Krebs is the mission to foster and facilitate research from fundamental biological, chemical and physical studies, through to translation into biotechnological and medical applications.

The Krebs Institute

The Krebs Institute was established at Sheffield University in 1988 as a multi-disciplinary, cross-departmental research arm to facilitate our programmes aimed at the greater understanding of biomolecular processes.

The members of the Institute are funded by grants from a wide variety of external bodies including BBSRC, EPSRC, MRC, the Wellcome Trust, EU, industry and the Royal Society.

The Krebs Institute is named after Sir Hans Krebs who, between 1935 and 1954, carried out his Nobel Prize winning biochemical experiments at Sheffield on the crucial metabolic cycle that bears his name.

Research Areas

An interdisciplinary approach to biology

Rapidly advancing technological developments have led to an explosion in genomic and biological data. To translate this information into predictive biology requires a full understanding of the molecular mechanisms underpinning life. The Krebs Institute has the ambitious aim of bridging this void in our knowledge, by harnessing complementary teams in a broad range of disciplines across the University to address crucial questions in biology.

To achieve this end, the Krebs Institute maintains, strengthens and stimulates collaborations between molecular, cellular and structural biologists, microbiologists, biochemists, chemists, physicists, theoreticians, information scientists and clinicians. The Institute is inclusive, driving science between whatever approaches are necessary to tackle complex and long-term problems.

The Krebs Institute Symposium 2016

14th June 2016

The Krebs Institute Symposium 2016 entitled “Research across the Boundaries” took place on Tuesday 14th June 2016.

The programme included two external keynote speakers, Professor Conrad Mullineaux (Queen Mary University of London) and Professor Matthew Fisher (Imperial College London) as well as talks from Sheffield scientists based in MBB, APS, BMS and the Medical School.

This year’s event saw the award of the inaugural Krebs Institute Development Prize for life science research, in mechanistic biology, carried out by an early career scientist at the University of Sheffield. The award aims to recognise achievement and future potential of an outstanding young scientist. The prize will include a £250 honorarium.

View the full programme here.

The Krebs Institute Symposium 2016 Programme

0930 Dr. Matt Johnson
0955 Dr. Allan Lawrie
1020 Prof. Kathryn Asycough
1045 Coffee
1115 Prof. Matthew Fisher, Imperial College London:
‘Genomic approaches to understanding then tackling emerging fungal threats’
1215 Dr. Ewald Hettema
1240 Dr. Estrella Luna Diez

1300 Lunch
1400 Krebs Institute Development Prize talks
5 x 12 minute talks plus 3 mins questions
1530 Coffee
1600 Prof. Conrad Mullineaux, Queen Mary University of London:
‘Cyanobacteria use micro-optics to sense light direction’
1700 Prize Presentation and wine reception


Exploring hidden worlds

The KrebsFest is a celebration of the scientific research of Sir Hans Krebs, winner of the Nobel Prize for Physiology or Medicine in 1953, for his pioneering work at the University of Sheffield.

At the festival we explore Krebs’ legacy through a series of public events and exhibitions including talks from Nobel Prize winners.

Find out more about KrebsFest at the festival website. 


Get in touch with us at the Krebs Institute

For further information, or to discuss collaborations, please contact the Director of the Krebs Institute:

Professor Simon Foster


Tel: +44-114-222-4411

The Krebs Institute, MBB, The University of Sheffield, Sheffield S10 2TN, U.K.